For pilots, treatment choice is an occupational medicine decision as much as a headache decision, so verify approval status, no-fly intervals, and operational consequences before prescribing.

Pilot migraine treatment must follow FAA medication approval rules; Some migraine preventives are permitted, while tricyclics and antiseizure drugs are prohibited; Abortive therapies carry mandatory no-fly intervals that affect treatment choice; Cluster headache is strictly unilateral and produces brief, extremely severe attacks; Cluster headache can appear in episodic or chronic patterns with different remission behavior