Use ICANS Risk Factors and EEG Findings to guide the working diagnosis and next step; let the main risk or management issue drive escalation, treatment choice, and follow-up.

That said, it is also very common to capture generalized periodic discharges, which can help guide anti-seizure management.; Having a severe bout of cytokine release syndrome prior to the neurotoxicity, or running into concurrent sepsis or acute kidney injury, also heavily predisposes them.; Individuals are significantly more vulnerable if they have pre-existing neurological disease, an abnormal baseline brain magnetic resonance imaging scan, or elevated baseline neurofilament light chains.; Single most common finding on an electroencephalogram is diffuse, generalized slowing.; Key management decisions should stay tied to the clinical pattern and follow-up needs.