Use the modern diagnostic approach to dystrophinopathies such as Duchenne and., dystrophinopathy be considered in adults with elevated creatine kinase and., and clinical features of Duchenne muscular dystrophy to frame the working diagnosis and next step; let it drive treatment choice rather than habit. Make dystrophinopathy be considered in adults with elevated creatine kinase and. the checkpoint that determines whether you escalate testing, narrow the differential, or change treatment.

Dystrophinopathy should remain on the differential at any age when CK is elevated and weakness is present; Young boys with classic weakness and a markedly elevated CK should go straight to genetic testing; Duchenne muscular dystrophy causes early proximal weakness, calf pseudohypertrophy, contractures, and scoliosis; Becker muscular dystrophy usually follows a milder and later course than Duchenne; Cardiac and functional monitoring matter because dystrophinopathies are multisystem disorders