For Dravet Syndrome and Juvenile Myoclonic Epilepsy Essentials, watch for Dravet syndrome: onset first year, prolonged febrile seizures (often unilateral), progresses to afebrile seizures + developmental delay, 70-80% caused by de novo SCN1A mutations, and Avoid sodium channel blockers (phenytoin, carbamazepine, lamotrigine) when choosing therapy, counseling about risk, planning monitoring, and deciding when closer follow-up or escalation is needed.

Dravet syndrome: onset first year, prolonged febrile seizures (often unilateral), progresses to afebrile seizures + developmental delay; 70-80% caused by de novo SCN1A mutations; Avoid sodium channel blockers (phenytoin, carbamazepine, lamotrigine); JME: adolescent onset, morning myoclonic jerks + GTCS + absences, sleep deprivation triggers; Valproate most effective JME treatment, lamotrigine can worsen myoclonus