High-yield points: GABA-ergic enhancement (valproate, barbiturates, benzodiazepines, gabapentin) Sodium channel blockade (phenytoin, carbamazepine, lamotrigine) T-type calcium channel targeting for absence seizures (ethosuximide)

u003culu003eu003cliu003eGABA-ergic enhancement (valproate, barbiturates, benzodiazepines, gabapentin)u003c/liu003eu003cliu003eSodium channel blockade (phenytoin, carbamazepine, lamotrigine)u003c/liu003eu003cliu003eT-type calcium channel targeting for absence seizures (ethosuximide)u003c/liu003eu003cliu003eBenzodiazepines increase chloride channel opening frequency; barbiturates prolong channel durationu003c/liu003eu003cliu003eCenobamate modulates both sodium channels and GABAu003c/liu003eu003cliu003eCYP450 inducers reduce oral contraceptive efficacy by ~5-foldu003c/liu003eu003c/ulu003e